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USE OF TRIFUNCTIONAL BISPECIFIC ANTIBODIES FOR THE TREATMENT OF TUMORS ASSOCIATED WITH CD133+/EpCAM+CANCER STEM CELLS
USE OF TRIFUNCTIONAL BISPECIFIC ANTIBODIES FOR THE TREATMENT OF TUMORS ASSOCIATED WITH CD133+/EpCAM+CANCER STEM CELLS
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机译:使用功能性双特异性抗体治疗与CD133 + / EpCAM +癌干细胞相关的肿瘤
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摘要
Use of a trifunctional bispecific antibody having the following properties of: a) binding to a T cell; b) binding to EpCAM as tumor-associated antigen on a tumor cell wherein the tumor cell additionally carries the membrane bound glycoprotein CD133; c) binding by its Fc portion to Fc receptor-positive cells for the preparation of a pharmaceutical composition for the destruction of cancer stem cells carrying the tumor-associated antigen EpCAM and the membrane bound glycoprotein CD133 in a population of patients suffering from a tumor.
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