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MODULATION OF INDUCIBLE NITRIC OXIDE (INOS) BINDING TO SPRY DOMAIN-CONTAINING SOCS-BOX PEPTIDES (SSB)
MODULATION OF INDUCIBLE NITRIC OXIDE (INOS) BINDING TO SPRY DOMAIN-CONTAINING SOCS-BOX PEPTIDES (SSB)
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机译:难熔一氧化氮(INOS)结合到含杂域的SOCS-BOX肽(SSB)的调制
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摘要
The present invention relates to methods of modulating the level of inducible nitric oxide synthase (iNOS) in a cell which comprises administering to the cell a compound which modulates binding of SPRY domain-containing SOCS box protein (SSB) to iNOS, and/or a compound which modulates SSB activity in the cell. Further provided are methods of treating or preventing disease in a subject by modulating the level of iNOS in a cell, as well as compounds which modulate binding of SSB to iNOS and compounds which modulate SSB activity.
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