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MESENCHYMAL STEM CELL IN WHICH ENDOSTATIN AND CARBOXYL ESTERASE ARE CONCURRENTLY OVEREXPRESSED AND PREVENTING, TREATING OR RECURRENCE SUPPRESSION METHOD OF GLIOMA BY USING THE SAME
MESENCHYMAL STEM CELL IN WHICH ENDOSTATIN AND CARBOXYL ESTERASE ARE CONCURRENTLY OVEREXPRESSED AND PREVENTING, TREATING OR RECURRENCE SUPPRESSION METHOD OF GLIOMA BY USING THE SAME
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机译:内膜抑素和羧甲基酯酶的间充质干细胞始终过量表达,并通过使用相同的方法预防,治疗或复发胶质瘤
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PURPOSE: A mesenchymal stem cell in which endostatin and carboxyl esterase are concurrently over expressed and preventing, treating or recurrence suppression method of glioma by using the same are provided to drastically prevent carcinogenesis and recurrence.;CONSTITUTION: In a mesenchymal stem cell, endostatin and carboxyl esterase are concurrently over expressed. A preventing, treating or recurrence suppression method of glioma includes a step of injecting the mesenchymal stem cell to all mammals except for human. A manufacturing method of human amniotic fluid-derived mesenchymal stem cell(AF-MSC) comprises the following steps: establishing positive number of primary cell cultivation in a minimum essential medium in which fetal bovine serum(ES-FBS) having 15% of embryonic stem cell, 2mM L-glutamine and 1% of penicillin streptomycin are contained, and 18% Chang culture medium B and 2% Chang culture medium C are supplemented; collecting cells by trypsinization for selective cultivation of AF-MSC; plating in DMEM low dextrose broth supplemented with 10% of FBS, 1% of penicillin streptomycin, 2mM L-glutamine and 4ng/mL basic fibroblast growth factor (bFGF: R&D); and obtaining morphologic interspecies population of the AF-MSC after second round of the subculture.;COPYRIGHT KIPO 2013
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