Precursor, intermediates and their salts of statin series for hyperlipemia and manufacturing method for them

摘要

The present invention relates to a starting material for manufacturing a bar Roche statin calcium salts formula represented by the formula (1) compound of B, Scheme 10] by the production process of the compound of Formula 1 as represented and Scheme 11, Scheme 12, Scheme 13, Scheme 14, Scheme 15, and Roche bar represented by the formula (2), as represented by Scheme 16 provides a statin calcium salt thereof. R & 1 & [Equation 10] [Equation 11] [Equation 12] [Equation 13] [Equation 14] [Equation 15] [Equation 16] R & 2 & Wherein R ¹ is a hydroxyl protecting group acetate, trichloroethyl acetate, trifluoroacetate, benzoate, trimethylsilyl, triethylsilyl, tripropylsilyl, triisopropylsilyl, and t- butyl-dimethyl- and any one selected from the group consisting of silyl, R ³ is any one selected from the group consisting of methyl, ethyl, isopropyl and phenyl, R ⁴ is a carboxylic acid protecting group as methyl, ethyl, propyl, isopropyl, n- butyl, which is one selected from the group consisting of t- butyl.