Transgenic Mice Overexpressing HIF-2amp;alpha; as an Animal Model of Arthritis and Uses Thereof

摘要

The present invention is a nucleotide sequence encoding (a) HIF-2α (hypoxia-inducible factor-2α); And (b) relates to a transgenic arthritic animal model obtained expression construct is from the switch except for the introduced human transgenic embryos, and which comprises a transcriptional control sequence which is combined (operatively linked) operatively to said nucleotide sequence will be. Transgenic mice with the recombinant expression vectors of the invention can be used as a very useful treatment of arthritis models that can be useful in the study of cartilage degenerative processes. Also, transgenic mice of the present invention may be applied to a method for screening a therapeutic agent for arthritis. ;