A system and a method for analysis and visualization of local clinical features, the identifying (34) of a first region of interest (roi) is made of one of a patient acquired medical image data set (32) and the extraction (36) of a characteristic data set, which a for the area of interest specific feature of interest represents. The system contains, in addition, the identification (38) of a second region of interest (roi) from the medical image data set, the extraction (40) of a said referencing record, the reference data which contains an expected behavior of the attribute of interest, comparing (44) of the feature data set with the set of generating (44) of a deviation metric of a deviation of the feature is of interest on the basis of the comparison, and generating (46) of a visual representation of the deviation metric.
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