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Design of stable and non-aggregating antibody Fc molecules through CH3 domain interface manipulation
Design of stable and non-aggregating antibody Fc molecules through CH3 domain interface manipulation
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机译:通过CH3域界面操作设计稳定且非聚集的抗体Fc分子
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摘要
The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
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