The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL-15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12)or combinations of both, and an interleukin receptor polypeptide portion, for example IL-15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.
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机译：本发明涉及治疗性多肽及其产生方法和在需要其的宿主生物中调节免疫应答的方法。特别地，本发明涉及向需要其的生物体施用有效量的包含淋巴因子多肽部分的预偶联的多肽复合物，例如IL-15（SEQ ID NO：5、6），IL- 2（SEQ ID NO：10，12）或两者的结合以及白介素受体多肽部分，例如IL-15Ra（SEQ ID NO：7，8），IL-2Ra（SEQ ID NO：9，11）或两者的组合，用于增强例如癌症，SCID，艾滋病或疫苗接种中的免疫系统;或抑制类风湿关节炎或狼疮的免疫系统。本发明的治疗复合物令人惊讶地显示出增加的半衰期和体内功效。
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