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CD19 antibody and method of use thereof

机译:CD19抗体及其使用方法

摘要

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
机译:本公开提供了分离的单克隆抗体,特别是以高亲和力特异性结合CD19的人单克隆抗体。还提供了编码此类CD19抗体的核酸分子,表达载体,宿主细胞和表达CD19抗体的方法。还提供了包含CD19抗体的免疫缀合物,双特异性分子和药物组合物。公开了用于检测CD19的方法以及用于治疗包括非霍奇金淋巴瘤在内的各种B细胞恶性肿瘤的方法。

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