Method of manufacturing a medical biodegradable poly-lactic acid by polycondensation of lactic acid catalyzed by creatinine

摘要

The present invention is a method of making a medical biodegradable polylactic acid by direct polycondensation of lactic acid catalyzed by creatinine. In the present invention, as a catalyst (creatinine CR is the product of arginine metabolism in the human body a biomass organic guanidine compounds) creatinine, commercially available, was used as a monomer for industrial lactic acid, the two-step weight solventless by condensation, I get a polylactic acid with high biosafety. In the present invention, without using a Suzu-rui catalyst having cytotoxic polylactic acid catalyst used has the biosafety and biocompatibility advanced, is synthesized does not contain toxic components other and any metal , and suitable carriers targeted drug and the controlled release formulation, the green processes and green catalyst was synthesized biodegradable polylactic advanced biosafety, the obtained raw material cost is likely to be implemented industrially cheap polymerization reaction is easy The molecular weight distribution of the product is small and the molecular weight is controlled within the range of 1.5~3.0 × 10 ^4. None [Selection Figure]