The transgenic non-human mammals, including inositol 1,4,5 and it trisphosphate receptor binding protein

摘要

It provides a transgenic non-human mammals including inositol it? 1,4,5? Trisphosphate receptor and (IP3R) binding protein. IP3R-binding protein and protein KRAP proteins such as (SEQ ID NO: 1~4), IP3R and (SEQ ID NO: 5 to 8) are attached, and this invention, IP3R activity inhibitor whose main component is the IP3R binding protein about. In addition, the present invention relates to transgenic non-human mammals including IP3R binding protein. In mice KRAP protein, binding sites of proteins KRAP IP3R is bound to present in the amino acid sequence region consisting of 19 amino acids of the 218-th from the 200th. IP3R binding sites in mouse KRAP protein of animal species of other, existing in the region corresponding to the amino acid sequence region consisting of 19 amino acids of the 218 th 200 th KRAP mouse protein.