首页> 外国专利> Novel Functionally Selective Ligands of Dopamine D2 Receptors

Novel Functionally Selective Ligands of Dopamine D2 Receptors

机译：多巴胺D2受体的新型功能选择性配体。

页面导航

摘要
著录项
相似文献

摘要

The present invention relates to novel functionally selective ligands of dopamine D2 receptors, FIG. 1 including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.

机译：本发明涉及多巴胺D 2受体的新型功能选择性配体。 1 包括激动剂，拮抗剂和反向激动剂。本发明进一步涉及这些化合物在治疗与D2受体有关的中枢神经系统疾病中的用途。 展开▼

著录项

公开/公告号US2013137679A1

专利类型

公开/公告日2013-05-30

原文格式PDF

申请/专利权人 JIAN JIN;BRYAN ROTH;STEPHEN FRYE;
展开▼

申请/专利号US201113807347

发明设计人 JIAN JIN;BRYAN ROTH;STEPHEN FRYE;
展开▼

申请日2011-07-01

分类号C07D403/12;A61K31/551;A61K31/4725;C07D417/12;C07D405/14;A61K31/55;A61K31/538;A61K31/4965;A61K45;A61K31/454;C07D471/04;C07D413/14;C07D241/04;C07D401/12;A61K31/496;C07D217/22;C07D403/02;

国家 US

入库时间 2022-08-21 16:48:25

相似文献

专利

外文文献

中文文献

1. 一种多巴胺D2受体双位配体型化合物和应用 [P] . 中国专利： CN113979915A . 2022-01-28

2. 用于多巴胺D2受体的成像配体 [P] . 中国专利： CN102223900A . 2011-10-19

3. Functionally selective ligands of dopamine D₂receptors [P] . 美国专利： US9156822B2 . 2015-10-13

机译：多巴胺D _{2 受体的功能选择性配体}

4. FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D₂ RECEPTORS [P] . 世界知识产权组织专利： WO2012003418A3 . 2012-05-18

机译：多巴胺D _{2 受体的功能选择性配体}

5. FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D₂ RECEPTORS [P] . 世界知识产权组织专利： WO2012003418A2 . 2012-01-05

机译：多巴胺D _{2 受体的功能选择性配体}

1. Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice [J] . Carlos Pereira Martins, Rodrigo Sebben Paes, Gabriela Mantovani Baldasso, 中国神经再生研究（英文版） . 2022,第002期

2. Tetrahydroisoquinolines functionalized with carbamates as selective ligands of D2 dopamine receptor [J] . Parravicini Oscar, Lucrecia Bogado M., Rojas Sebastian, Journal of molecular modeling . 2017,第9期

3. Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. [J] . Mottola DavidM, Kilts JasonD, Lewis MechelleM, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2002,第3期

4. Dopamine/Serotonin Receptor Ligands.10: SAR Studies on Azecine-type Dopamine Receptor Ligands by Functional Screening at Human Cloned D_1,D_(2L) and D_5 Receptors with a Microplate Reader Based Calcium Assay Lead to a Novel Potent D_1/D_5 Selective A [J] . Barbara Hoefgen, Michael Decker, Patrick Mohr, Journal of Medicinal Chemistry . 2006,第2期

5. Inverse agonism at dopamine D2 receptors: a receptor recalcitrant to high levels of constitutive activation [C] . Thierry Wurch, Elisa A. Boutet-Robinet, Petrus J. Pauwels Fundaci髇 Dr. Antonio Esteve . 2003

6. Dopamine D2 receptor functional selectivity as a mechanism of atypical antipsychotic drug action. [D] . Urban, Jonathan Douglas. 2006

7. Receptor Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity [O] . Sean M. Peterson, Thomas F. Pack, Marc G. Caron -1

8. Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity. [O] . Sean M Peterson, Thomas F Pack, Marc G Caron 2015

1. STUDIES　ON　DOPAMINE　RECEPTORS　AND　TETRAHYDROPROTOBERBERINES．Ⅱ．QUANTUM　CHEMISTRY　OF　LIGAND－RECEPTOR　INTERACTION [J] . Yun TANG ,Kai Xian CHEN ,Hua Liang JIANG . 中国化学快报：英文版 . 1996,第3期

2. Functionally diverse ligands modulate different activation states of the formyl peptide receptor 2, a G protein-coupled receptor [J] . Shuo ZHANG ,Hao GONG ,Richard Dequan YE . 中国药理学与毒理学杂志 . 2017,第010期

3. Effects of 17iβ/i-Estradiol on Dopamine D2 Receptors in Thiamine-Deficient Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight [J] . Seydou Silué ,Abdoulaye Bacirc . 生物科学与医学（英文） . 2019,第11期

4. Effects of Ovariectomy and 17iβ/i-Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight [J] . Abdoulaye Ba ,Seydou Silué ,Brahima Bamba . 行为与脑科学期刊（英文） . 2018,第1期

5. 精神分裂症患者多巴胺D2受体和多巴胺转运体基因表达水平与临床症状的关系 [C] . LIU Liang ,刘亮 ,CHENG Zao-huo . 中国中西医结合学会精神疾病专业委员会第十一届学术年会 . 2012

6. 新型Tc标记多巴胺D2受体显像剂的研究 [A] . 郝彬 . 2001