SYSTEMS AND METHODS FOR X-RAY FLUORESCENCE COMPUTED TOMOGRAPHY IMAGING WITH NANOPARTICLES

摘要

X-ray fluorescence computed tomography (XFCT) using polychromatic x-rays is provided herein. The XFCT of the presently disclosed subject matter allows for the imaging of various cells loaded with metallic nanoparticles using polychromatic diagnostic energy x-rays. Both imaging of nanoparticles distributed within a cell and the quantification of nanoparticle concentration within the cell, in some configurations, may be accomplished. The x-ray source may, in some examples, provide a pencil beam or a cone/fan beam x-ray configuration.