Immune system synthetic activators based on bacterial stress proteins and on fragments thereof

摘要

immune system activators zalozenu00e9 in bacterial stress proteins hsp65 chaperoninovu00e9 families and their fragmentech.based on a systematic survey imunoaktivacnu00edch characteristics pentapeptidovu00fdch sequences with vyuzitu00edm kombinatoricku00fdch peptide libraries were identified pentapeptidy aelee, aelte, lelde,and aelde.the target peptide sequences were further dimerizovu00e1ny through linkeru with vyuzitu00edm amide (ad) or thiomocovinovu00e9 (tm) links.and thus obtained, dimers, along with monomeric peptides were subjected to immunological tests.the most interesting thing results were obtained with monomeric peptides lelde and aelde,which, thanks to its specific receptor (kd cd69 custody order pm) zpusobovaly very effective proliferation of cd69 + and raise my lymphocyte count is only natural killing without any influence on activation inducedapoptosu. according to the invention are, for instance, in pentapeptidy vyuzitelnu00e9 recovery immunodeficient state infekcnu00edch and tumour disease.