POLYMER AND PROCESS FOR OBTAINING SAME, PHARMACEUTICAL COMPOSITION IN NANOPARTICULATE FORM, PROCESS AND KIT FOR PREPARATION THEREOF AND METHOD OF TREATING PATHOLOGICAL CONDITIONS IN HUMANS OR ANIMALS

摘要

The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.