selective inhibitors of norepinephrine reuptake-serotonin for treating fibromyalgia syndrome, chronic fatigue syndrome and pain

摘要

Use of an effective amount of dual reuptake inhibitor of serotonin and norepinephrine NE 5-HT (SNRI NE 5-HT) which is not a tricyclic antidepressant, or a pharmaceutically acceptable salt thereof, as sole Active ingredient in the manufacture of a medicament to treat fibromyalgia syndrome (FMS) and / or the same fisiológicosasociados symptoms in an animal subject; wherein the SNRI NE 5-HT has a inhibition ratio NE: 5-HT in elintervalo 2: 1 to 10: 1, and wherein the SNRI NE 5-HT is an aminocyclopropane compound of the formula I: wherein: R represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, nitro or amino; n represents the value 1 or 2; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, aryl, substituted aryl, alkaryl, substituted alkaryl and with the adjacent nitrogen atom, a heterocycle, R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, and the adjacent atom denitrógeno, a heterocycle, or a pharmaceutically acceptable salt thereof.