HRSV F protein conformation stabilized pre-fusion and neutralizing antibodies specific thereto.

摘要

F protein VRSH in forming pre-fusion stabilized and specific neutralizing antibodies against the same. # The present invention provides a fusion protein (F protein) of human respiratory syncytial virus (HRSV) in pre-fusion stabilized useful conformation to identify or designing antibodies and other molecules that bind to it for diagnosis, prevention and / or treatment of infections caused by viruses of the Paramyxoviridae family, genus Pneumovirus preferably, more preferably by HRSV. The present invention also relates to a method of obtaining this protein as well as antibodies and aptamers against the same, which are useful for diagnosis, treatment and / or prevention of these infections.