Hemoglobins of compatible mammalian blood plasma, crosslinked and conjugated with poly (alkylene oxides) as carriers of artificial medical oxygen, their preparation and use

摘要

Derivative compatible hemoglobin with human and animal plasma, wherein the hemoglobin estáreticulada covalently via a bifunctional crosslinker for selected proteins butane diepoxide, divinyl sulfone, a diisocyanate, a hydroxysuccinimidyl di-N-ester, diimidoéster or a dialdehyde or glicolaldehídoutilizando excess molar 3 to 60 times based on monomeric hemoglobin, and then a poly (dealquileno oxide) with a molecular weight (molar mass) between 200 and 5,000 g / mol which is a product binding poly (dealquileno oxide) with a molecule masks a terminal hydroxy group of the poly (alkylene oxide) is unidocovalentemente to hemoglobin.