Controlled release preparations of oxcarbazepine having sigmoidal release profile

摘要

A pharmaceutical formulation for administration once daily of oxcarbazepine consisting múltiplesunidades, where each unit comprises (a) oxcarbazepine, (b) at least one agent that enhances solubilidadde oxcarbazepine selected from a group comprising surfactants, complexing agents, molecular entrapment agents, pH modifying agents, and hydration promoting agents; and (c) at least one promoter of the release agent, wherein said agent promoting the release comprises a polímeroque has a pH dependent solubility and incorporated into each unit, and wherein each unit has a perfilde release for different oxcarbazepine other units.