COMBINATION OF A NITROGEN MUSTARD ANALOGUE AND IMATINIB FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA

摘要

The invention relates to a combination which comprises (a) a nitrogen mustardanalogue selected from chlorambucil, chlornaphazine, estramustine,mechlorethamine, mechlorethamine oxide hydrochloride, navembichin,phenestrine, prednimustine, trofosfamide or uracil mustard and (b) 4-(4-methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4pyridin-3-yl)pyrimidin-2-ylamino)phenylJ-benzamide of formula (I) or a pharmaceutically acceptable saltthereof, the invention pertains to the use of said combination for thetreatment chronic lymphocytic leukemia.