INDENOINDOLE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS OR OPTICAL ISOMERS THEREOF, PREPARATION METHOD FOR SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING VIRAL DISEASES

摘要

The present invention relates to a indanonederivative, pharmaceutically acceptable salts or opticalisomers thereof, a preparation method for same, and apharmaceutical composition containing same as an activeingredient for preventing or treating viral diseases. Theindanone derivatives according to the present invention notonly have low cyto-toxicity, but may also demonstrateutility as pharmaceutical compositions for preventing ortreating viral diseases such as: polio, viral paralysis,acute hemorrhagic conjunctivitis, viral meningitis,handfoot-mouth disease, blistering diseases, hepatitis A,myositis, myocarditis, pancreatitis, viral diabetes,epidemic myalgia, encephalitis, flu, herpes angina,foot-and-mouth disease, asthma, chronic obstructive pulmonarydisease, pneumonia, sinusitis, otitis media, and the like,since excellent antiviral activity against picornavirusessuch as Coxsack - ie virus, enterovirus, echovirus, poliovirus, rhinovirus, and the like, have been demonstrated.Indanone derivatives include those represented by formula1:(see formula 1)wherein,A1, A2, A3, A4, D, E, Z, G1, G2, G3, G4, X, and Y arerespectively as defined herein.