Microbial N- and O-demethylation of a thebaine derivative

摘要

#$%^&*AU2011203283B220130502.pdf#####ABSTRACT The invention provides a process for the N-demethylation or the N- and 0-demethylation of a thebaine derivative which process comprises fermenting the derivative with a biocatalyst selected from the 5 filamentous fungi from Cunninghamella dalmatica NRRL 1394, Cunninghamella echinulata NRRL 1387, Cunninghamella echinulata NRRL 1384, Cunninghamella echinulata 0 ATCC 36190, Cunninghamella echinulata ATCC II 585a, Cunninghamella echinulata ATCC 9244, Cunninghamella polymorpha NRRL 1395, or Rhizopus nigricans Z5/lin a basal fermentation medium at a temperature of at least 250C and not more than 340C, for a period of time of at least 3 days.