ALTERNATIVE SPLICING MODULATORS AND SPLICE VARIANTS AND THEIR USE IN THE CONTROL AND DETECTION OF PLURIPOTENCY AND DIFFERENTIATION

摘要

Nucleotide sequences encoding novel splice variants of FOXP1, proteins encoded by the novel splice variants and antibodies thereto are disclosed. In addition, methods are described for maintaining a population of homogenous self-renewing and pluripotent stem cells, suppressing stem cell differentiation, and reprogramming somatic cells into pluripotent stem cells comprising the use of the novel splice variants. Also disclosed are modulators of alternative splicing such as MBNL1 and MBNL2 and methods and uses thereof for promoting pluripotency.