Provided is application of SAA1β/β(1.5/1.5) homozygote in liver cirrhosis prognosis diagnosis and/or liver cirrhosis diagnosis, and in preparation of a liver cirrhosis prognosis diagnosis and/or liver cirrhosis diagnosis reagent. Human SAA1β/β homozygote and non-SAA1β/β homozygote are detected through real-time fluorescence quantitative allele-specific PCR, so as to detect liver cirrhosis susceptible populations.
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