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MRNA AS BIOMARKERS FOR LIVER INJURY OR OTHER LIVER PERTURBATIONS
MRNA AS BIOMARKERS FOR LIVER INJURY OR OTHER LIVER PERTURBATIONS
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机译:MRNA作为肝损伤或其他肝扰动的生物标记
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摘要
The present invention provides a method for assessing the likelihood or for detecting the presence of liver perturbation in an individual. The method is particularly useful for detecting drug-induced liver injury (DILI) or other forms of hepatotoxicity or hepatic perturbation. The method comprises measuring the level of at least one RNA biomarker comprising mRNA and comparing the measured level to an appropriate reference value for the sample type and RNA biomarker type, and wherein a significant difference between the measured level and the reference value is indicative of liver perturbation.
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