POLYMORPHS OF N-(4-(3-FLUOROBENZYLOXY)-3-CHLOROPHENYL)-6-(5-((2-(METHYLSULFINYL)ETHYLAMINO)METHYL)-2-FURANYL)-QUINAZOLINE-4-AMINEXYLENE SULFONATE AND PREPARATION METHOD AND USES THEREOF

摘要

The invention relates to the polymorphs of N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfinyl)ethylamino)methyl)-2-furanyl)-quinazoline-4-aminexylene sulfonate (compound I) used as tyrosine kinase inhibitors. In particular, the invention relates to the crystal forms A, B, C and D of compound I. The invention also relates to a preparation method for the polymorphs of compound I, and comprises its pharmaceutical compositions and their pharmaceutical uses. The polymorphs of compound I of the invention are efficient tyrosine kinase inhibitors.