NON-INVASIVE BIOMARKERS FOR EOSINOPHILIC ESOPHAGITIS

摘要

Methods and compositions disclosed herein generally relate to methods of providing or enhancing a diagnosis of eosinophilic esophagitis (EoE), by identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for gastrointestinal tract dysfunction, particularly as those responses relate to EoE. In particular, the invention relates to identifying one or more biomarkers associated with EoE, obtaining a sample from a patient having at least one indication of EoE, then quantifying from the sample an amount of one or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome. The invention further relates to diagnostic kits, tests, and/or arrays that can be used to quantify the one or more biomarkers associated with EoE.