METHOD OF TREATING EXPERIMENTAL LEPROUS INFECTION

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, specifically dermatology, and may be used for treating experimental leprous infection. For the purpose for suppression of leprous mycobacteria propagation in mice pads infected intraplantarily by Shepard's method, therapeutic agents are used. The therapeutic agents are presented by a herbal tea. The tea contains ground equal weight proportions of common licorice roots Glycyrrhiza glabra, parviflorous yarrow herb Achillea micrantha and sandy everlasting blossom Helichrisum arenarium. The tea is extracted in prepared 40% aqueous surgical ethanol in the relation of 1 portion of the raw material to 3 portions of ethanol and kept with agitation for 6 days. Then the mixture is added with an equal proportion of a buffer containing, wt %: calcium chloride 0.014, potassium chloride 0.04, potassium dihydrogen phosphate 0.006, magnesium sulphate 0.02, magnesium chloride 0.02, sodium chloride 0.08, sodium bicarbonate 0.035, disodium phosphate 0.024, glucose 0.1. The mixture is kept for another 4 days in a cool place with daily stirring, filtered andoclaved for three times at 0.5 atm for 10 minutes; the prepared extract is introduced into experimental animals in dose 0.4-0.6 mg/kg of body weight daily through a probe into oesophagus.;EFFECT: presented invention provides higher therapeutic effectiveness ensured by substantial suppression of leprous mycobacteria growth in mice pads, higher activity of completed phagocytosis M leprae in animal macrophagues, optimal selection of doses with no side effects.;5 ex, 10 tbl