Producing polymer sensor particles for aprotic medium, comprises providing e.g. monomer mixture dissolved in aprotic solvent, generating chain of droplets, forming metal nanoparticle-containing polymer composite particles and washing

摘要

Producing polymer sensor particles for aprotic medium containing many metal nanoparticles, comprises: (i) providing a mixture of a liquid provided in substance, or monomer or monomer mixture dissolved in an aprotic solvent and a metal salt-containing solution in a solvent solubilizing the monomer or the monomer mixture; (ii) generating a chain of droplets from the mixture by a microfluidic reactor; (iii) forming metal nanoparticle-containing polymer composite particles by photo-polymerization of chain droplets of the mixture; and (iv) repeated washing of the resulting sensor particles. Producing polymer sensor particles for aprotic medium containing many metal nanoparticles, comprises: (i) providing a mixture of a liquid provided in substance, or monomer or monomer mixture dissolved in an aprotic solvent and a metal salt-containing solution in a solvent solubilizing the monomer or the monomer mixture; (ii) generating a chain of droplets from the mixture by a microfluidic reactor, where the droplets are produced by injection of the reaction mixture into a fluid carrier phase, preferably polydimethylsiloxane, which is not miscible or partially miscible with the reaction mixture, such that a two phase system is formed; (iii) forming metal nanoparticle-containing polymer composite particles by photo-polymerization of chain droplets of the mixture, where a reduction of the metal ions is carried out to metal nano-particles; and (iv) repeated washing of the resulting sensor particles, where the plasmonic and surface-enhanced Raman scattering metal nanoparticles are fixed in a swellable aprotic polymer matrix. Independent claims are also included for: (1) producing protic sensor particles containing several or many non-spherical metal nanoparticles, comprising providing a mixture of a hydrophilic monomer dissolved in protic solvent, a protic crosslinking agent and a colloidal solution of pre-synthesized metal nanoparticles in a polar solvent, generating a chain of droplets from the mixture by microfluidic reactor, where the droplets are produced by injection of the reaction mixture into a fluid carrier phase, preferably polydimethylsiloxane, which is not miscible or partially miscible with the reaction mixture, such that a two phase system is formed, forming metal nanoparticle-containing polymer composite particles by photochemically initiated polymerization of chain droplets of the mixture, and repeated washing of the resulting hydrophilic particle sensor; and (2) aprotic or protic non-spherical metal nanoparticle-containing sensor particles produced by the above mentioned method.