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It can exist at the building a bridge die boron connotation micellar null underwater which makes the neutron capture medical therapy

机译:它可以存在于建筑物中,在水下存在桥死硼的含义,胶束无效,这使得中子俘获药物治疗

摘要

PPROBLEM TO BE SOLVED: To provide a polymer conjugate of a boron compound and a hydrophilic/hydrophobic type block copolymer existing as a stable polymer micelle in a biological environment. PSOLUTION: This polymer conjugate includes at least a structure in which a molecule of a boron compound is crosslinked with two molecules of hydrophilic/hydrophobic type block copolymers via a covalent bond, and the boron compound is bifunctional having two polymerizable functional groups and the hydrophilic/hydrophobic type block copolymer has a polymerizable functional group on the end of its hydrophobic block, and the covalent bond is formed by mutual polymerization reaction of the polymerizable functional group of the boron compound and the polymerizable functional group of the block copolymer. The boron compound is represented by figured formula, wherein the black circle represents BH, LSB3/SBrepresents a methylene bond or the like and Z represents a polymerizable functional group. PCOPYRIGHT: (C)2011,JPO&INPIT
机译:<要解决的问题:提供硼化合物与亲水/疏水型嵌段共聚物的聚合物共轭物,其在生物环境中作为稳定的聚合物胶束存在。

解决方案:该聚合物共轭物至少包括以下结构:其中硼化合物的分子通过共价键与两个亲水/疏水型嵌段共聚物分子交联,并且该硼化合物是具有两个可聚合官能团的双官能团,并且亲水/疏水型嵌段共聚物在其疏水嵌段的末端具有可聚合的官能团,并且通过硼化合物的可聚合的官能团与嵌段共聚物的可聚合的官能团的相互聚合反应形成共价键。硼化合物用下式表示:黑色圆圈表示BH,L 3 SB表示亚甲基键等,Z表示聚合性官能团。

版权:(C)2011,日本特许厅&INPIT

著录项

  • 公开/公告号JP5522361B2

    专利类型

  • 公开/公告日2014-06-18

    原文格式PDF

  • 申请/专利权人 国立大学法人 筑波大学;

    申请/专利号JP20090217359

  • 发明设计人 角谷 省吾;長崎 幸夫;大石 基;

    申请日2009-09-18

  • 分类号A61K51/00;C07F5/02;A61K9/107;A61K47/34;A61K31/69;A61P35/00;

  • 国家 JP

  • 入库时间 2022-08-21 16:16:52

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