Methods and systems for quantitative image quality assessment of an imaging system, such as an in vessel visual inspection system, having a target, an image capture device and a computer. The target includes one or more image features with varying spatial resolutions and predetermined spatial frequencies. The image capture device is configured to capture an image of the target. The computer includes a processor, a memory, and computer executable instructions. The computer is configured to receive the captured image, prepare one or more intensity profiles across the captured image responsive to the predetermined spatial frequencies, and determine a modulation transfer function responsive to the one or more intensity profiles.
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