Immunotherapy using allo NKT cells and cells for which the α chain region of the T cell antigen receptor (TCR) gene is reconstituted into uniform Vα-Jα and banking of the cell-derived NKT cells

摘要

The present invention relates to an NKT cell obtained by in vitro differentiation of a cell in which the α chain region of the T cell antigen receptor gene is reconstituted into a uniform Vα-Jα in an NKT cell receptor-specific manner. An immunocytotherapeutic agent, comprising the allogeneic individual that does not match the genotype of at least one of the MHC loci with the NKT cell, is provided. The present invention also provides a human cell or a bank of NKT cells derived from human cells in which the α chain region of the T cell antigen receptor (TCR) gene is reconstituted into a uniform Vα-Jα. The agent and cell bank of the present invention are useful for the prevention and / or treatment of cancer, infectious diseases, allergic diseases or autoimmune diseases.