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COMPOSITIONS AND METHODS FOR RECOGNITION OF RNA USING TRIPLE HELICAL PEPTIDE NUCLEIC ACIDS
COMPOSITIONS AND METHODS FOR RECOGNITION OF RNA USING TRIPLE HELICAL PEPTIDE NUCLEIC ACIDS
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机译:使用三螺旋肽核酸识别RNA的组合物和方法
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摘要
Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases formed stable and sequence selective triple helices with double stranded RNA at physiologically relevant conditions. The M-modified PNA displayed unique RNA selectivity by having two orders of magnitude higher affinity for the double stranded RNAs than for the same DNA sequences. Preliminary results suggested that nucleobase-modified PNA could bind and recognize double helical precursors of microRNAs.
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