首页>
外国专利>
Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
展开▼
机译:设计用于抵抗先天宿主反应的无毒溶瘤性单纯疱疹病毒株
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ134.5 genes of the virus have been deleted and each replaced with an interferon-resistance gene that is expressed as an immediate-early gene. The present invention also relates to a pharmaceutical composition that includes the modified herpes simplex virus of the present invention and a pharmaceutically acceptable vehicle for in situ administration to tumor cells. Also provided in the present invention are methods for killing tumor cells in a subject and for immunizing a subject against an infectious disease, cancer, or an autoimmune disease that involve administering to a subject the modified avirulent, oncolytic herpes simplex virus of the present invention.
展开▼