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Anti-HCV monoclonal antibody as a medicament for the therapeutic treatment and prevention of HCV infections

机译：抗HCV单克隆抗体作为药物治疗和预防HCV感染

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摘要

The present invention relates to the monoclonal antibody e20 or a functional fragment thereof as a medicament for the therapeutic treatment and prevention of HCV infections. The e20 antibody is able to bind all of the known HCV genotypes and exhibits a strong neutralising activity against the virus, in particular towards genotypes 1a, 1b, 2a, and 4. A pharmaceutical composition is also described for the treatment or prevention of HCV infections, which comprises the monoclonal antibody e20 or a functional fragment thereof, and pharmaceutically acceptable excipients, carriers or diluents.

机译：本发明涉及作为治疗和预防HCV感染的药物的单克隆抗体e20或其功能片段。 e20抗体能够结合所有已知的HCV基因型，并且对病毒表现出强大的中和活性，尤其是对1 I ，1 b ，2 4。还描述了用于治疗或预防HCV感染的药物组合物，其包含单克隆抗体e20或其功能片段，以及药学上可接受的赋形剂，载体或稀释剂。 展开▼

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公开/公告号US8623363B2

专利类型

公开/公告日2014-01-07

原文格式PDF

申请/专利权人 ROBERTO BURIONI;MASSIMO CLEMENTI;
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申请/专利号US200913141071

发明设计人 ROBERTO BURIONI;MASSIMO CLEMENTI;
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申请日2009-12-21

分类号A61K39/395;

国家 US

入库时间 2022-08-21 15:59:06

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3. ANTI-HCV MONOCLONAL ANTIBODY AS A MEDICAMENT FOR THE THERAPEUTIC TREATMENT AND PREVENTION OF HCV INFECTIONS [P] . 欧洲知识产权局专利： EP2376119B1 . 2015-04-22

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