'COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT, PREVENTION OR IMPROVEMENT OF ONE OR MORE, SYMPTOMS OF A DISORDER MEASURED BY ENDOTHELIN IN A SUBJECT, METHOD OF INHIBITION OF EUMA ENDOTHELIN TO AN ETE METHOD OF ACTIVITY AND METHOD OF ACTIVITY AND METHOD OF METHOD AND ETHODY BY THE ENDOTHELINE RECEPTOR '

摘要

Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.