Antigen Binding Protein that binds specifically to oncostatin m (OSM) and Inhibits the binding of OSM with the gp130 receptor but does not interact with residues of site II; polynucleotide that encodes; Pharmaceutical composition that comprises; and Use thereof for treating a disease or Disorder inflated Matorio.

摘要

The present invention concerns a method of humanising antigen binding proteins and fragments. The invention particularly concerns a method of humanising antibodies, in particular those which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. Further disclosed are antigen binding proteins produced by such methods pharmaceutical compositions, screening and medical treatment methods.