Nucleic acids encoding a fusion polypeptide having ß(1,4) -n-acetylglucosaminyl transferase iii activity or ß(1,4)-galactosyl transferase activity and comprising a golgi localization domain of human mannosidase ii and uses thereof

摘要

The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.