Oral use of immunogenic composition against Clostridium difficile infections, the use of Bacillus subtilis as carriers for antigens and extracted recombinant coat protein genes and FbpA and Flid antigens

摘要

the subject invention is oral immunogenic composition against infection clostridium difficile, which contains fragments of the genes two surface proteins: - fbpa expressed sequence 1 and - flid expressed sequence 2, which constitute the antigen.in addition, subject invention is application of spores bacillus subtilis as carriers for antigens that are presented on the surface of sclerotia, for the manufacture of oral compositions for the treatment of infections immunogennej clostridium difficile.the invention also includes isolated recombinant genes encoding protein antigens and fbpa coat and flid of nucleotide sequence and aminokwasowej.