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New amide derivatives of mycophenolic acid, the process for preparing amide derivatives of mycophenolic acid, and the use of new amide derivatives of mycophenolic acid for the manufacture of an immunosuppressant in particular reducing the risk of transplant rejection

机译:麦考酚酸的新酰胺衍生物,麦考酚酸的酰胺衍生物的制备方法,以及麦考酚酸的新酰胺衍生物在制备免疫抑制剂中的用途,特别是降低了移植排斥的风险

摘要

the subject of the invention are new derivatives of mycophenolic acid amide linkages of general formula 2, where r is h or ch3, or ch2ph or ch (ch3) 2, or ch2ch (ch3) 2, or ch2ch2cooh or ch (oh) ch3, or (ch2) 3nh (c = nh) nh2, r means ch3 or h. the subject invention are also ways otrzymywa nia linkages derived of mycophenolic acid with the general formula 2.the invention also includes the use of new linkages derived of mycophenolic acid with the general formula 2, where r is h or ch3, or ch2ph or ch (ch3) 2, ch2ch (ch3) 2 or ch2ch2cooh or ch (oh) ch3, or (ch2) 3nh (c = nh) nh2, r is ch3 or h for the manufacture of immunosuppressant. especially at risk of transplant rejection.
机译:本发明的主题是通式2的霉酚酸酰胺键的新衍生物,其中r是h或ch3,或ch2ph或ch(ch3)2,或ch2ch(ch3)2,或ch2ch2cooh或ch(oh)ch3,或(ch2)3nh(c = nh)nh2,r表示ch3或h。本发明也是通过通式2的麦考酚酸衍生的自酶联键的方法。本发明还包括使用通过通式2的麦考酚酸衍生的新键合,其中r为h或ch3,或ch2ph或ch( ch3)2,ch2ch(ch3)2或ch2ch2cooh或ch(oh)ch3或(ch2)3nh(c = nh)nh2,r是ch3或h,用于制备免疫抑制剂。特别是有移植排斥的风险。

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