Antibacterial hydrogel and its use in orthopedics

摘要

An antibacterial hydrogel comprising water, a derivative of hyaluronic acid and an antibacterial agent, in which: - the derivative of hyaluronic acid comprises hyaluronic acid, or a salt thereof, with a molecular weight between 50,000 and 3,500,000 Da in the fractions of N-acetyl-D-glucosamine, in which chains of a biodegradable and biocompatible polyester with a molecular weight between 3,000 and 900,000 Da have been inserted, in an amount such that the derivative comprises between 1 and 15 of said polyester chains per 100 repetitive units of D-glucuronic acid / N-acetyl-D-glucosamine of hyaluronic acid; - the concentration of said hyaluronic acid derivative or salt thereof is between 1 and 30% w / v; and - the antibacterial agent is chosen from among antibiotics, antifungal metal ions and combinations thereof, and has a concentration between 0.001% and 80% w / v.