DOSAGE FORM FOR ORAL ADMINISTRATION CAPABLE OF BEING ADHERED TO FLOWING GASTRIC MUCOSA

摘要

The present invention relates to a dosage form for oral administration capable of being adhered to the flowing gastric mucosa, comprising mucosa-adhesive needles between a corrosive polymer layer and a swellable polymer layer, and independently identical or different pharmacologically active substances. According to the present invention, the dosage form for oral administration capable of being adhered to the flowing gastric mucosa can effectively control the in vivo release and absorptivity of pharmacologically active substances through the combination of desired corrosive and swellable polymers thereby facilitating the control of a blood drug concentration, comprises pharmacologically active substances in each of a corrosive layer and a swellable layer thereby showing a pharmacological synergistic effect, and exhibits superior mucosa adhesion and sustained efficacy of a drug compared with conventional a Geomatrix system dosage form and a mucosa-adhesive dosage form, by the adhesion of the mucosa-adhesive needles exposed by the corrosion of the corrosive layer to the gastric mucosa, and thus can be useful as an extended release drug delivery system for oral administration.