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METHOD FOR PRODUCING VIRUS-LIKE PARTICLES OF NODAVIRUS, YEAST CELL LINE EXPRESSING SAME, AND VACCINE COMPOSITION CONTAINING SAME
METHOD FOR PRODUCING VIRUS-LIKE PARTICLES OF NODAVIRUS, YEAST CELL LINE EXPRESSING SAME, AND VACCINE COMPOSITION CONTAINING SAME
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机译:制备诺达氏病毒样颗粒的方法,酵母细胞系表达相同的疫苗和包含其的疫苗组合物
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摘要
The present invention relates to a method for producing virus-like particles of nodavirus, a yeast cell line expressing the same, and a vaccine composition containing the same. According to the method of the present invention, it is possible to mass produce high-quality virus-like particles of nodavirus by expressing a nodavirus capsid protein through a yeast expression system and purifying the same by chromatography. The virus-like particles of nodavirus prepared by the method of the present invention can be very useful as an antigen of a vaccine against nodavirus infection. In addition, the present invention provides a recombinant yeast strain expressing a nodavirus capsid protein, and a vaccine composition containing the recombinant yeast strain or a cultured product thereof.
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