OSTEOSARCOMA DIAGNOSTIC AND PROGNOSTIC METHODS

摘要

This disclosure describes, in one aspect, a method that generally includes analyzing a tissue sample from a subject for expression of a 14q32 miRNA, wherein a decrease in expression of the 14q32 miRNA compared to a normal control indicates that the subject has or is at risk of having osteosarcoma. In some embodiments, expression of the 14q32 miRNA of no more than 10% of a normal control further indicates that the subject has or is at risk of having an aggressive osteosarcoma.