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COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION
COMPOSITION FOR TREATING LIVER CANCER IN HUMANS BASED ON RHENIUM-188 AND METHOD FOR PREPARING SUCH A COMPOSITION
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机译:基于R188的人类肝癌治疗组合物及制备该组合物的方法
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摘要
Liver cancer in humans is the fifth most common cancer in the world. Chemoembolization is an alternative strategy to surgery and radiotherapy that is attractive due to the effectiveness thereof and the limitation of side-effects for the patient. Formulations according to prior art have problems of stability and effectiveness which limit the clinical use thereof. The present invention therefore relates to a composition for treating liver cancer in humans including a complex of the following formula (I): [M(RCS3)2(RCS2)] where M is 188Re with high activity, that is to say greater than 3.7 Gbq, and a lipophilic organic base emulsified with an aqueous phase, R is an alkyl, cycloalkyl or aryl group, unsubstituted or substituted with one or more substituents selected from among halogen atoms, a hydroxyl group, alkyl groups and alkoxy groups.
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