Phenyl derivatives or pharmaceutically acceptable salts thereof, preparation method thereof, and composition for the prevention, improvement and treatment of vascular endothelial cell related-diseases or diabetes mellitus containing the same as an active ingredient

摘要

This invention is phenyl derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and this active ingredient containing the diabetes, relates to a composition for prevention, improvement or treatment of endothelial-related disorders such as diabetic complications, inhibition phenyl derivatives according to the present invention is to effectively control the glucose utilization, created risk factors of diabetic complications of advanced glycation endproducts highly effective, the treatment that the vitreous of the eye blood vessel diameter is widened by a pathological hyperglycemia in an animal model (zebrafish) as well as (prevention) that the excellent effect, diabetic retinopathy is induced in animal models (SD rats) prevent the destruction of the retinal blood vessel barrier, and the protein constituting the dense Eau rudin seams increases, indicate the effect of reducing significantly the increase in pathological angiogenesis growth factor because of diabetes, diabetic complications related to vascular endothelial cells, such as diseases prevention, amelioration or treatment composition can be used as a useful there.