Nanoconstructions nucleic acids in flexible working environment, nanobiosensors AT ITS BASIS AND METHODS FOR THEIR PREPARATION

摘要

1. nanoconstructions nucleic acid, which is immobilized in a flexible working medium particle lyotropic cholesteric liquid-crystalline dispersion rigid double-stranded nucleic acid molecules having spatially developed structure that retains the original structure, abnormal optical properties, chemical and biological activity of said dispersion with changing the physical state of the working medium, wherein: - in the particle layers quasinematic nucleic acid molecule crosslinked between adjacent do other using cross-linking providing an orientation of said molecules in space and interconnected to form a three-dimensional structure of the particle, - said particle is placed within the array elastic working fluid of a predetermined size and configuration, comprising pre-immobilized distributed at a predetermined distance from one another, the particles of said dispersion - a flexible working medium has an optically isotropic and transparent in the wavelength range of light radiation, resistance to biodegradation pronits impermeability to compounds from the external environment and has physical condition, providing the ability to extract from the array working medium fragment predetermined size and configuration, comprising at least one said chastitsu.2. Nanostructures of claim 1, characterized in that the working medium is a flexible synthetic polymer hydrogel, the resulting three-dimensional radical suspension polymerization of said particles in the macromonomer of polyethylene glycol having a terminal methacryl gruppy.3. Nanostructures of claim 1, by