COMPOSITION OF THE CONTRAST ENVIRONMENT WITH THE EFFECT OF CONTRAST AMPLIFICATION BY INCLUSION OF A HIGHLY CONCENTRATED CONTRAST AGENT

摘要

1. The composition of the contrast medium containing an aqueous contrast agent selected from the group consisting of iopenol, yotrolan, yogheksol, yoversol, yoksilan, iodixanol and yobitridol, in an amount of from 360 mgI / ml to 450 mgI / ml.2. The contrast medium composition according to claim 1, wherein the aqueous contrast agent is yogexol. The contrast medium composition according to claim 2, which contains an aqueous contrast agent in a concentration of from 380 mgI / ml to 420 mgI / ml. The composition of the contrast medium according to claim 2, which contains an aqueous contrast agent at a concentration of 380 mgI / ml. The contrast medium composition according to claim 2, which contains an aqueous contrast agent at a concentration of 400 mgI / ml. The contrast medium composition according to claim 2, which contains an aqueous contrast agent at a concentration of 420 mgI / ml. The contrast medium composition according to claim 1, which further comprises an aqueous buffer, sterile water for injection, a chelating agent and a pH adjusting agent. The contrast medium composition according to claim 7, wherein the aqueous buffer is tromethamine. The contrast medium composition according to claim 7, wherein the chelating agent is at least one selected from the group consisting of ethylenediamine, disodium calcium edetate and disodium edetate. The composition of the contrast medium according to claim 1, the pH of which is from 7.0 to 8.0.11. The contrast medium composition according to claim 3, wherein the CEA and CEP compositions of the contrast medium containing an aqueous contrast agent in a concentration of from 360 mgI / ml to 450 mgI / ml correspond to the following ratio with the CEA and CEP compositions of the contrast medium containing an aqueous contrast agent at a concentration of 350 mgI / ml CEA CEACEP CEP12. The contrast medium composition according to claim 4, wherein the CEA and CEP contrast medium compositions comprising