MULTITARGET INHIBITORS OF TUMOUR GROWTH BASED ON LINEAR HETEROARENE ANTHRACENEDIONES

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to derivatives of linear tetracyclic heteroarene anthracehediones, which contain in side chains residues of halogen acetamidines and correspond to formula: as well as to their pharmacologically acceptable salts, where X, Y, Z independently stand for CH- or Nh-groups or heteroatoms, selected from O, N and S, forming five-member heteroarene, optionally substituted with alkyl; Hal independently stands for fluorine, chlorine, bromine or iodine atom; m and n independently stand for number from 2 to 4 and equal quantity of spacer CH₂-groups, connecting aminogroups in peri-positions of heteroarene anthracenedione with nitrogen atoms of residues of halogenacylamidines, located in side chain; W stands for substituents, independently selected from the group: amino, hydroxy, alkoxy, fluorine; k stands for number of substituents W in anthracenedione fragment, independently equal from 0.;EFFECT: novel compounds, which can be applied in medicine for therapy of oncological diseases, have been obtained.;3 tbl, 4 dwg, 12 ex