Method for measuring magnetic information, in particular the magnetic AC susceptibility, of magnetic nanoparticles (markers)

摘要

Method with an atomic force microscope for the spatially resolved determination of nanoparticles, which are placed in or on a sample, and measurement of the magnetic information of the nanoparticles, in particular the magnetic AC susceptibility, wherein the diameter of the nanoparticles in the range of 5 nm to 50 nm and these magnetic dipole moments, which amplify or weaken an external magnetic flux density, characterized in that the nanoparticles and the sample are excited with an alternating magnetic field, so that the total flux density is changed in the vicinity of the nanoparticles, the sample to be examined is three-dimensional rasterized , the magnetic peak of the atomic force microscope is used to determine the change in the total magnetic flux density under the influence of the alternating magnetic field on the sample, by measuring the deflection of the magnetic peak, the exciting alternating magnetic field a frequency from 10 kHz to 100 MHz and the method is used in the room temperature range, which allows use under biological conditions.